Review: St John's Wort may be less effective than previously thought in people with depression.

نویسنده

  • Y C Janardhan Reddy
چکیده

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St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.

The chemical composition of St. John's wort has been well-studied. Documented pharmacological activities, including antidepressant, antiviral, and antibacterial effects, provide supporting evidence for several of the traditional uses stated for St John's wort. Many pharmacological activities appear to be attributable to hypericin and to the flavonoid constituents; hypericin is also reported to ...

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A meta-analysis on the efficacy and safety of St John’s wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults

OBJECTIVE The aim of the study was to investigate the efficacy and safety of St John's wort extract and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. METHODS Databases were searched for studies comparing efficacy and/or safety of St John's wort extract with SSRIs in depression from 1966 to April 2015. Stata software was used for statistical analysis. RESULT...

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St John's wort and depression.

St. John's wort is a plant with yellow flowers that has been used for centuries for health purposes, such as for depression and anxiety. This fact sheet answers some frequently asked questions about St. John's wort and depression, and summarizes what the science says about its effectiveness and the research being done. • Studies suggest that St. John's wort is of minimal benefit in treating maj...

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Pharmacokinetic interactions of Hypericum perforatum L. (St John's wort) with conventional drugs: a review of clinical studies

Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...

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Adverse reactions to St John's Wort.

OBJECTIVE To report 2 cases of adverse reactions to St John's wort, a popular herbal treatment for depression. METHOD We present 2 case histories and review the existing literature regarding St John's wort. RESULTS St John's wort may cause serotonin syndrome in sensitive patients. In addition, St John's wort may be associated with hair loss. CONCLUSIONS For clinical reasons, it is importa...

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عنوان ژورنال:
  • Evidence-based mental health

دوره 7 4  شماره 

صفحات  -

تاریخ انتشار 2004